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1. Lab 이름
□ 국문 (예: 당뇨 및 대사질환 연구실):
뇌교종 연구실
□ 영문 (예: Laboratory of diabetes and metabolic research):
Laboratory of Glioma Research
2. Lab 소속교수
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국문이름 |
영문이름 |
Degree (MD/PhD/MD.PhD) |
소속교실 |
PI 여부 |
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박철기 |
Chul-Kee Park |
MD.PhD |
신경외과학교실 |
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3. laboratory 소개
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Research Focus
(200단어
이내 ) |
국문 |
악성뇌교종은 가장 흔한 원발성 뇌종양 중 하나이면서도 아직까지도 대표적인 난치병입니다. 본 연구실은 이러한 뇌교종에 대한 연구를 집중적으로 진행하고 있습니다.
본 연구실은 실험을 통해 바로 임상에 적용할 수 있는 연구결과를 생산하는 것을 목표로 풍부하게 보유하고 있는 뇌교종 환자 샘플에서 발견되는 분자생물학적 특징과 임상 경험을 기반으로 뇌교종의 발생기전 규명, 치료저항성 극복을 위한 항암표적인자 개발을 수행하고 있으며,collaboration을 통한 genome profiling과 metabolomics 기반 연구를 진행하고 있습니다. |
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영문 |
Our laboratory studies the malignant gliomas, the most common primary tumor in the brain but still one of the most devastating human diseases remains to be cured. A major focus of our research involves investigation of glioma biomarker and evaluation of gliomagenesis mechanisms.
Insights from molecular signatures in tumor tissue are the major interest for the studies on glioma characterization, treatment resistance, and possible biomarkers. We have used genomic profiling and epigenetic research to investigate the molecular markers specific for glioma itself and its unique characteristics. The investigation of metabolomics engaged in gliomagenesis and it clinical application is the current research focus.
The purpose of our laboratory is to produce results that can be applied immediately to clinical field. |
4. 대표논문 (selected publications, 5개 이내)
(형식 예: Lee WW, Shin MS, Kang Y, Lee N, Jeon S, Kang I. The relationship ofcytomegalovirus (CMV) infection with circulatory IFN-α levels and IL-7receptor α expression on CD8+ T cells in human aging.Cytokine. 2012 58(3):332-5.)
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1 |
Kim JW, Park CK, Park SH, Kim YH, Han JH, Kim CY, Sohn CH, Chang KH, Jung HW. Relationship between radiological characteristics and combined 1p and 19q deletion in World Health Organization grade III oligodendroglialtumours. J NeurolNeurosurg Psychiatry. 2011 82(2):224-7 |
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2 |
Park CK, Kim J, Yim SY, Lee AR, Han JH, Kim CY, Park SH, Kim TM, Lee SH, Choi SH, Kim SK, Kim DG, Jung HW. Usefulness of MS-MLPA for detection of MGMT promoter methylation in the evaluation of pseudoprogression in glioblastoma patients. NeuroOncol. 2011 13(2):195-202. |
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Choi SA, Wang KC, Phi JH, Lee JY, Park CK, Park SH, Kim SK. A distinct subpopulation within CD133 positive brain tumor cells shares characteristics with endothelial progenitor cells. Cancer Lett. 2012 Nov 28;324(2):221-30. |
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4 |
Park CK, Kim JE, Kim JY, Song SW, Kim JW, Choi SH, Kim TM, Lee SH, Kim IH, Park SH. The Changes in MGMT Promoter Methylation Status in Initial and Recurrent Glioblastomas. TranslOncol. 2012 5(5):393-7. |
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5 |
Sunwoo L, Choi SH, Park CK, Kim JW, Yi KS, Lee WJ, Yoon TJ, Song SW, Kim JE, Kim JY, Kim TM, Lee SH, Kim JH, Sohn CH, Park SH, Kim IH, Chang KH. Correlation of apparent diffusion coefficient values measured by diffusion MRI and MGMT promoter methylation semiquantitatively analyzed with MS-MLPA in patients with glioblastoma multiforme. J MagnReson Imaging. 2013 37(2):351-8. |
5. Lab 사진 촬영 여부 표시
PI 소개
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 본인 사진 파일을 보내주시기 바랍니다.
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이름(국문) |
박철기 |
이름(영문) |
Park Chul-Kee |
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Degree (MD/PhD/MD.PhD) |
MD.PhD |
소속교실 |
신경외과학교실 |
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Office 주소(영문) |
Dept. of Neurosurgery, SNUH, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea |
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Lab 주소 (영문) |
Dept. of Neurosurgery, SNUH, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea |
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Telephone |
+82-2-(2072)-(0347) |
FAX |
+82-2-(741)-(8594) |
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E-mail |
nsckpark@snu.ac.kr |
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Curriculum Vitae
(영문. 6항목 이내) |
2011-Present. Associate professor, Department of Neurosurgery, SNUH |
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2006-2011. Assistant professor, Department of Neurosurgery, SNUH |
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2004-2005, Fellowship, Department of Neurosurgery, SNUH |
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1997-2001, Residency, Department of Neurosurgery, SNUH |
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1996-1997, Internship, Seoul National University Hospital |
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1990-1996, Seoul National University, College of Medicine |
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Honors/Awards
(영문, 3항목 이내) |
2012 Scientific article prize (Korean Brain Tumor Society) |
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2011 Excellent Young Paper Award (Asian Society for Neuro-oncology) |
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2008 Woo Jeong Hyun Scientific article prize (Korean Neurosurgical Society) |
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Current research topics
(영문, 개조식 작성, 5항목 이내) |
1. Genomic profiling for gliomas |
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2. Clinical application of metabolic markers of glioma |
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3. Molecular backgrounds of fluorescence-guided surgery |
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4. Epigenetic characteristics of gliomas |
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5. |
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Research Topic을 설명하는 그림이나 표가 있으면 파일로 보내주시기 바랍니다. (optional) |
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Research Keywords
(영문, 5개이내) |
glioma |
NGS |
metabolomics |
5-ALA |
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Selected Publications
(5개이내) |
Kim JW, Park CK, Park SH, Kim YH, Han JH, Kim CY, Sohn CH, Chang KH, Jung HW. Relationship between radiological characteristics and combined 1p and 19q deletion in World Health Organization grade III oligodendroglialtumours. J NeurolNeurosurg Psychiatry. 2011 82(2):224-7 |
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Park CK, Kim J, Yim SY, Lee AR, Han JH, Kim CY, Park SH, Kim TM, Lee SH, Choi SH, Kim SK, Kim DG, Jung HW. Usefulness of MS-MLPA for detection of MGMT promoter methylation in the evaluation of pseudoprogression in glioblastoma patients. NeuroOncol. 2011 13(2):195-202. |
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Choi SA, Wang KC, Phi JH, Lee JY, Park CK, Park SH, Kim SK. A distinct subpopulation within CD133 positive brain tumor cells shares characteristics with endothelial progenitor cells. Cancer Lett. 2012 Nov 28;324(2):221-30. |
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Park CK, Kim JE, Kim JY, Song SW, Kim JW, Choi SH, Kim TM, Lee SH, Kim IH, Park SH. The Changes in MGMT Promoter Methylation Status in Initial and Recurrent Glioblastomas. TranslOncol. 2012 5(5):393-7. |
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Sunwoo L, Choi SH, Park CK, Kim JW, Yi KS, Lee WJ, Yoon TJ, Song SW, Kim JE, Kim JY, Kim TM, Lee SH, Kim JH, Sohn CH, Park SH, Kim IH, Chang KH. Correlation of apparent diffusion coefficient values measured by diffusion MRI and MGMT promoter methylation semiquantitatively analyzed with MS-MLPA in patients with glioblastoma multiforme. J MagnReson Imaging. 2013 37(2):351-8. |
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